Lettuce Big Vein Virus Info – Treating Big Vein Virus Of Lettuce Leaves


By: Amy Grant

Lettuce isn’t difficult to grow, but it sure does seem to have its share of issues. If it isn’t the slugs or other insects devouring the tender leaves, it’s a disease like lettuce big vein virus. What’s big vein virus of lettuce? Read on to learn how to identify lettuce with big vein virus and how to manage big vein lettuce virus.

What is Big Vein Virus of Lettuce?

Big vein lettuce virus is a viral disease. Both Mirafiori Lettuce Big Vein Virus (MLBVV) and Lettuce Big Vein Associate Virus (LBVaV) are associated with big vein infected lettuce plants, but only MLBVV has been identified as a causal agent. It is certain, however, that this viral disease is transmitted by an oomycete, Olpidium virulentus, previously known as O. brassicae – also known as water mold.

This virus is fostered by wet, cool conditions such as cool spring weather. It has a large host range and can survive for at least eight years in the soil.

Symptoms of Big Vein Lettuce Virus

As the name suggests, plants infected with big vein lettuce virus have abnormally large leaf veining. Also, sometimes only a rosette forms and no head, or heads are generally stunted in size. Leaves are also often mottled and ruffled.

Management of Lettuce with Big Vein Virus

Because the disease remains viable for such a lengthy period in the soil, one would think that crop rotation would be a cultural method for control, and it is if the rotation is many years long.

In garden spaces with a history of big vein, avoid planting susceptible crops specifically during cool wet spring and fall, and in poorly draining soil.

Use big vein resistant cultivars and select garden space that has not previously been planted with lettuce. Always remove crop detritus rather than working it into the soil to minimize infection.

Treating the soil with steam can reduce the population of both the virus and the vector.

While severely infected plants become so deformed they certainly can’t be sold, those with minimal damage can be harvested and, in the case of commercial farming, marketed. The home gardener can use his or her own judgment on whether or not the lettuce should be consumed, but it is more a matter of aesthetics than anything else.

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Symptoms of lettuce mosaic vary greatly. Leaves of plants that are infected at a young stage are stunted, deformed, and (in some varieties) show a mosaic or mottling pattern. Such plants rarely grow to full size head lettuce varieties that are infected early fail to form heads.

Plants that are infected later in the growth cycle will show a different set of symptoms. These plants may reach full size, but the older outer leaves will be yellow, twisted, and otherwise deformed. On head lettuce, the wrapper leaves often will curve back away from the head. Developing heads may be deformed. In some cases, brown, necrotic flecks occur on the wrapper leaves


Host gene expression shutoff

Vesicular stomatitis virus matrix protein blocks nuclear pores, resulting in host mRNA nuclear export inhibiton This shutoff of host gene expression prevents effective antiviral response by the infected cell.

Inhibition of host Interferon induction

Rabies nucleoprotein plays a role in inhibition of RIG-I antiviral signaling Rabies phosphoprotein may inhibit IRF-3 phosphorylation

Inhibition of host type I interferon signaling

Rabies phosphoprotein may inhibit STAT-I antiviral pathway signaling by preventing nuclear localization of STAT dimers upon activation.


Bos L, Huijberts N (1990) Screening for resistance to big vein disease of lettuce. Crop Prot 9:446–452. doi:10.1016/0261-2194(90)90135-T

Campbell RN (1965) Weeds as reservoir hosts of the lettuce big-vein virus. Can J Bot 43:1141–1149. doi:10.1139/b65-127

Colariccio A, Chaves ALR, Eiras M, Chagas CM, Lenzi R, Roggero P (2003) Presence of lettuce big-vein disease and associated viruses in a subtropical area of Brazil. Plant Pathol 52:792. doi:10.1111/j.1365-3059.2003.00901.x

Dellaporta S, Wood J, Hicks JB (1983) A plant DNA minipreparation: Version II. Plant Mol Biol Rep 1:19–21. doi:10.1007/BF02712670

Eenink A, Groenwold HR, Dieleman FL (1982) Resistance of lettuce (Lactuca) to the leaf aphid Nasanovia ribisnigri. 1. Transfer of resistance from L. virosa to L. sativa by interspecific crosses and selection of resistant breeding lines. Euphytica 31:291–300. doi:10.1007/BF00021643

Fujii H, Sasaya T, Takezaki A, Ishikawa K, Fujino M (2003) Resistance to lettuce big-vein disease in lettuce cultivars. J Jpn Soc Hortic Sci 72:315–317

Hayes RJ, Ryder EJ (2007) Introgression of novel alleles for partial resistance to big vein disease from Lactuca virosa into cultivated lettuce. HortScience 42:35–39

Hayes RJ, Wintermantel WM, Nicely PA, Ryder EJ (2006) Host resistance to Mirafiori lettuce big-vein virus and Lettuce big-vein associated virus and virus sequence diversity and frequency in California. Plant Dis 90:233–239. doi:10.1094/PD-90-0233

Jagger IC, Chandler N (1934) Big vein, a disease of lettuce. Phytopathology 24:1253–1256

Koopman WJM, Guetta E, van de Wiel CCM, Vosman B, Van den Berg RG (1998) Phylogenetic relationships among Lactuca (Asteraceae) species and related genera based on ITS-1 DNA sequences. Am J Bot 85:1517–1530. doi:10.2307/2446479

Koopman WJM, Zevenbergen MJ, Van den Berg RG (2001) Species relationships in Lactuca s.l. (Lactuceae, Atseracaea) inferred from AFLP fingerprints. Am J Bot 88:1881–1887. doi:10.2307/3558364

Latham LJ, Jones RAC (2004) Deploying partially resistant genotypes and plastic mulch on the soil surface to suppress spread of lettuce big-vein disease in lettuce. Aust J Agric Res 55:131–138. doi:10.1071/AR03138

Lebeda A, Ryder EJ, Grube R, Doležalová I, Křístková E (2007) Lettuce (Asteraceae Lactuca spp.). In: Singh RJ (ed) Genetic Resources, Chromosome Engineering and Crop Improvement. CRC Press, Baco Raton FL, pp 378–453

Lebeda A, Doležalová I, Feráková V, Astley D (2004) Geographical distribution of wild Lactuca species (Asteraceae, Lactuceae). Bot Rev 70:328–356. doi:10.1663/0006-8101(2004)070[0328:GDOWLS]2.0.CO2

Lot H, Campbell RN, Souche S, Milne RG, Roggero P (2002) Transmission by Olpidium brassicae of Mirafiori lettuce virus and Lettuce big vein virus, and their roles in lettuce big-vein etiology. Phytopathology 92:288–293. doi:10.1094/PHYTO.2002.92.3.288

Maisonneuve B, Chupeau MC, Bellec Y, Chupeau Y (1995) Sexual and somatic hybridization in the genus Lactuca. Euphytica 85:281–285. doi:10.1007/BF00023957

Navarro JA, Botella F, Maruhenda A, Sastre P, Sánchez-Pina MA, Pallas V (2004) Comparative infection progress analysis of Lettuce big-vein virus and Mirafiori lettuce virus in lettuce crops by developed molecular diagnosis techniques. Phytopathology 94:470–477. doi:10.1094/PHYTO.2004.94.5.470

Roggero P, Ciuffo M, Varia AM, Accotto GP, Masenga V, Milne RG (2000) An ophiovirus isolated from lettuce with big vein symptoms. Arch Virol 145:2629–2642. doi:10.1007/s007050070012

Roggero P, Lot H, Souche S, Lenzi R, Milne RG (2003) Occurrence of Mirafiori lettuce virus and Lettuce big-vein virus in relation to development of big vein symptoms in lettuce crops. Eur J Plant Pathol 109:261–267. doi:10.1023/A:1023060830841

Rosales IM, Sepulveda P, Bruna A (2004) First report of Lettuce big-vein virus and Mirafiori lettuce virus in Chile. Plant Dis 88:1286. doi:10.1094/PDIS.2004.88.11.1286C

Ryder EJ, Robinson BJ (1995) Big-vein resistance in lettuce: Identifying, selecting, and testing resistance cultivars and breeding lines. J Am Soc Hortic Sci 120:741–746

Thompson RC, Ryder EJ (1961) Descriptions and pedigrees of nine varieties of lettuce. Technical bulletin no. 1244. Agricultural Research Service, U.S. Department of Agriculture, Washington D.C., 19p

Walsh JA (2004) Effects of some biotic and abiotic factors on symptom expression of lettuce big-vein virus in lettuce. (Lactuca sativa). J Hortic Sci 69:927–935


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